2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Progesterone Receptor

Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

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Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (94):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0437S2
    Progesterone-13C3
    		Agonist 99.60%
    Progesterone-13C3 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
    Progesterone-<sup>13</sup>C<sub>3</sub>
  • HY-12738
    PF-3882845
    		Antagonist 99.90%
    PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM.
    PF-3882845
  • HY-B0648R
    Medroxyprogesterone (Standard)
    		Agonist 99.29%
    Medroxyprogesterone (Standard) is the analytical standard of Medroxyprogesterone. This product is intended for research and analytical applications.
    Medroxyprogesterone (Standard)
  • HY-B1095S1
    Chlormadinone acetate-d6-1
    		Agonist ≥99.0%
    Chlormadinone acetate-d6-1 is deuterium labeled Chlormadinone acetate.
    Chlormadinone acetate-d<sub>6</sub>-1
  • HY-B1089
    Ethynodiol diacetate
    		Agonist 99.85%
    Ethynodiol diacetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ethynodiol diacetate
  • HY-13676S
    Megestrol acetate-d3
    		Inhibitor
    Megestrol acetate-d3 is the deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway[1][2][3][4][5].
    Megestrol acetate-d<sub>3</sub>
  • HY-13683S1
    Mifepristone-13C,d3
    		Antagonist
    Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Mifepristone-<sup>13</sup>C,d<sub>3</sub>
  • HY-B0084S2
    Dienogest-d6
    		Agonist
    Dienogest-d6 is deuterium labeled Dienogest.
    Dienogest-d<sub>6</sub>
  • HY-13683S
    Mifepristone-d3
    		Antagonist
    Mifepristone-d3 is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].
    Mifepristone-d<sub>3</sub>
  • HY-B0111S1
    Drospirenone-d4-1
    		Agonist
    Drospirenone-d4-1 is deuterium labeled Drospirenone.
    Drospirenone-d<sub>4</sub>-1
  • HY-111614S
    Melengestrol acetate-d6
    		Activator
    Melengestrol acetate-d6 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].
    Melengestrol acetate-d<sub>6</sub>
  • HY-B0257S
    Levonorgestrel-d8
    		Agonist
    Levonorgestrel-d8 is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives[1][2]. Levonorgestrel-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Levonorgestrel-d<sub>8</sub>
  • HY-16508S
    Ulipristal acetate-d6
    		Antagonist
    Ulipristal acetate-d6 is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma[1][2].
    Ulipristal acetate-d<sub>6</sub>
  • HY-106827
    Trimegestone
    		Inhibitor
    Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.
    Trimegestone
  • HY-16508R
    Ulipristal acetate (Standard)
    		Antagonist
    Ulipristal acetate (Standard) is the analytical standard of Ulipristal acetate. This product is intended for research and analytical applications. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.
    Ulipristal acetate (Standard)
  • HY-B0084S
    Dienogest-d4
    		Agonist
    Dienogest-d4 is deuterium labeled Dienogest.
    Dienogest-d<sub>4</sub>
  • HY-105634
    Nomegestrol
    		Agonist
    Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
    Nomegestrol
  • HY-B1095R
    Chlormadinone acetate (Standard)
    		Agonist
    Chlormadinone acetate (Standard) is the analytical standard of Chlormadinone acetate. This product is intended for research and analytical applications.
    Chlormadinone acetate (Standard)
  • HY-B0084S1
    Dienogest-d5
    		Agonist
    Dienogest-d5 is deuterium labeled Dienogest.
    Dienogest-d<sub>5</sub>
  • HY-119482
    Cymipristone
    		Antagonist
    Cymipristone (ZXH-951), a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy.
    Cymipristone